Define upstroke and downstroke?

Awave is produced in a rope. the wave has a speed of 33 m/s and a frequency of 22 hz.

Asubject in a clinical research trial experiences a serious, unanticipated adverse drug experience. how should the investigator proceed, with respect to the irb, after the discovery of the adverse event occurrence? a. do not report the adverse drug experience to the irb since it is a common adverse experience.b. report the adverse drug experience to the irb only if there are several other occurrences.c. report the adverse drug experience as part of the continuing review report.d. report the adverse drug experience in a timely manner, in keeping with the irb's policies and procedures, using the forms or the mechanism provided by the irb.

This is one type of line graph in which the independent variable is time plotted on the x axis and the dependent variable, also numerical, is plotted on the y axis.