How did missouri compromise (1820) challenge state rights

well, it was a very difficult decision because passed a bill granting Missouri statehood as a slave state under the condition that slavery was to be forever prohibited in the rest of the Louisiana Purchase north of the 36th parallel, which runs approximately along the southern border of Missouri.

Explanation:

disease was the number one killer of native peoples. they had had little exposure to the diseases of europe. this led to some villages being almost completely wiped out and some tribes destroyed.