What was the major issue between northern and southern states after 1820?

slavery

Explanation:

The issue of slavery caused tension between the North and the South. In the North, the antislavery movement had slowly been gaining strength since the 1830s. Abolitionists believed that slavery was unjust and should be abolished immediately. Many Northerners who opposed slavery took a less extreme position.

theodore roosevelt challenged william to a duel, whoever won, got their policy sent to congress. it ended up in a stalemate, and both men were injured and sent to the hospital.