Malaria is a disease that is spread by mosquitoes. Mosquitoes lay eggs in stagnant water. Which of the following methods would help to control the number of mosquitoes? (i) Taking medicines that prevent malaria.

(ii) Put a thin film of oil on the surface of the water in a big pool.

(iii) Keeping the surroundings dry.

(iv) spraying chemical that kills insects.

Only (i)

Only (ii) and (iii)

Only (i), (ii) and (iii)

Only (ii), (iii) and (iv)

Adouble-blinded trial for a new indication is conducted under an ind comparing two (2) marketed drugs, at twice the approved prescribed doses. on day 2, subject 603 had difficulty breathing. although it was life-threatening initially, subject 603 was treated and discharged directly from the emergency department after complete recovery. on day 5, subject 20 had a headache, which led to hospitalization and required blood pressure lowering medications. these episodes cannot be explained on the basis of the pharmacological property of either drug or the subjects' medical histories. the investigator would submit an sae report for