Sexual problems stemming from sources typically occur when the physical body is incapable of responding appropriately, regardless of the sexual activities that are occurring.

Sexual problems stemming from Biological sources typically occur when the physical body is incapable of responding appropriately, regardless of the sexual activities that are occurring..
For example, Men with diabetes is more likely to develop erectile dysfunction because they tend to have problems within their blood vessels that prevent the blood from rushing to their sexual organ. 

It hurts for them at first then they get used to it