Based on the topic sentence for main fact 2, which supporting details would you expect to read in the paragraph? 1. hippos capsize boats. they trample people. they bite to protect their young. 2. hippos drown hunters. they drown tourists. they drown natives. 3. hippos kill more than elephants. they kill more than lions. they kill more than snakes. 4. hippos weigh a lot. they can hide underwater. they can climb small hills.

Read this excerpt from "edward jenner and the history of smallpox and vaccination.” smallpox was introduced to europe sometime between the fifth and seventh centuries and was frequently epidemic during the middle ages. the disease greatly affected the development of western civilization. the first stages of the decline of the roman empire (ad 108) coincided with a large-scale epidemic: the plague of antonine, which accounted for the deaths of almost 7 million people. the arab expansion, the crusades, and the discovery of the west indies all contributed to the spread of the disease. unknown in the new world, smallpox was introduced by the spanish and portuguese conquistadors. the disease decimated the local population and was instrumental in the fall of the empires of the aztecs and the incas. similarly, on the eastern coast of north america, the disease was introduced by the early settlers and led to a decline in the native population. before it reached the new world, smallpox played a role in