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Chemistry, 27.11.2019 20:31 ComicSans10

Thiamine (vitamin b1) deficiency diseases have a lower prevalence now than in the past. however, they are seen as beriberi in some developing regions and in regions of crisis, and as wernicke-korsakoff syndrome in some alcoholics. one type of beriberi causes neurological symptoms such as weakness, fatigue, and loss of sensations. what is a possible explanation for these symptoms? thiamine is necessary for gluconeogenesis. hexokinase requires thiamine. coenzymes of the pentose phosphate pathway require thiamine as a precursor. thiamine is a precursor to the cofactor for succinyl coenzyme a synthetase. the brain uses glucose, metabolized in glycolysis and the citric acid cycle, as its main energy source.

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