How would a drug that blocks acetylcholine receptors at the motor end plate affect skeletal muscle? how would a drug that blocks acetylcholine receptors at the motor end plate affect skeletal muscle?

Blockade of the acetylcholine receptors at the neuromuscular junction will lead to decreased or inhibited depolarization of the involved muscle leading to flaccid paralysis. This is similar in presentation to myasthenia gravis when there is autoimmune destruction of acetylcholine receptors at the neuromuscular junction.

Genetic engineering is the answer.