Which of the following best explains the chemical nature of the substrate as it relates to the enzyme's active site and functioning? A) The shape and charge of the substrate need to match enzyme active site for binding, activation, and catalysis.
B) The pH of the substrate must be compatible with an enzymes active site for binding, activation, and catalysis
C) The substrate and enzyme must have identical bonds for binding, activation and catalysis to occur
D) The size of the substrate needs to match an enzyme active site for binding, activation and catalysis