Please help A somatic stem cell in G1 of the cell cycle receives a growth factor signal binding to a receptor tyrosine kinase. Place the following cellular events in the order they would be expected to occur.
Ligand binds to the receptor
The cell is stimulated to proceed from G1 to S phase
Sister chromosomes separate and are pulled to opposite poles of the cell
A molecular signal verifies that all DNA has been replicated and any mutations have been repaired, and the cell proceeds to enter the mitotic phase.
Cross phosphorylation of RTK kinase domains takes place.
DNA Replication takes place
Kinetochore microtubules make attachments to the kinetochores
Cytokinesis separates the cellular materials into two new daughter cells
Intracellular signal proteins relay the signal to the cell interior and nucleus.
The cell proceeds from S phase to G2
DNA condenses, the nuclear envelope fragments, and the microtubule networks reorganizes to form the mitotic spindle.
Receptor dimerization occurs
Duplicated chromosomes align at the midline of the cell due to the “tug of war” between opposing kinetochore microtubules/motor proteins.
The nuclear envelope begins to reform, DNA de-condenses and microtubules are rearranged into their interphase configuration
A molecular signal confirms that all sister chromatids are correctly attached to opposing kinetochores and cohesins are cleaved.