A mutation of the proteolytic enzyme Trypsin (described in Section 6.1) results in a stable covalent bond between one of the catalytic amino acids of the protease and its protein substrate. Which of the following are probably true? a. The enzyme would become inactive.
b. The enzyme and substrate would be stuck together.
c. The delta-G of the proteolysis reaction would change.
d. The rate of the catalyzed reaction would increase.

b. The enzyme and substrate would be stuck together.

Explanation:

Enzymes are proteins whose active site binds to specific chemical reactants (i.e., substrates), thereby forming a complex that is similar to the interaction between a lock and its key. This active complex lowers the energy of the reaction and promotes a conformational change in the substrate to break down it into multiple products. When the enzyme contains mutations in its active site, the ability to bind the substrate is altered. In this case, the enzymatic reaction can't occur because the interaction enzyme-substrate doesn't produce an active complex.

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explanation:

ans.

in united states (us), the first leading cause of death for both women and men is heart diseases that leads to more than half of the deaths. heart diseases develop due to narrow arteries, buildup of plaque in blood capillaries that arises difficulties in blood flow.

the second leading cause of deaths in us is cancer that affects individuals of all ages. it develops due to uncontrolled growth and spread of tumor cells, which results in death if the not controlled or treated.

the third leading cause of deaths in us is copd or chronic obstructive pulmonary disease. it includes difficulty in breathing, chest infections, and persistent cough. smocking is a leading cause of copd and around 80% of copd deaths occur due to smoking.

thus, the correct answer is 'option). cancer, copd, and heart disease.'