This hypothesis states that viruses originated from more complex cells
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The hypothesis that states that viruses originated from more complex cells is called the regressive hypothesis.

Explanation:

The regressive hypothesis -also called degenerative hypothesis- raises the possibility that viruses originally were cells that behaved as symbionts or parasites of other cells, and this condition of dependence could have originated the disappearance of genes, becoming structures formed by nucleic acid inside a viral capsid (virus).

Some evidence gathered to support this theory suggests that some bacteria, such as rickettsia, need to parasitize a cell in order to replicate, just as viruses do.

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Virus characteristics link

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enzyme active site and substrate specificity

enzymes bind with chemical reactants called substrates. there may be one or more substrates for each type of enzyme, depending on the particular chemical reaction. in some reactions, a single-reactant substrate is broken down into multiple products