One of the key considerations when developing antibiotics is targeting bacteria without harming the infected individual. protein synthesis in bacteria and eukaryotes are different enough that this is a good target for antibiotics that inhibit translation machinery. in fact, antibiotics that inhibit bacterial translation can do so in different ways. select the specific mechanisms by which certain antibiotics interfere with translation. blocks rna synthesis initiation by inhibiting bacterial rna polymerase causes misreading, which produces abnormal proteins acts as a peptidyl-transferase complex competitive inhibitor inhibits enzymes that are involved in peptidoglycan cross-linking □