Structure-based drug design strategies often devise competitive inhibitors that bind to certain enzyme active sites. for example saquinavir and indinavir are designed hiv protease inhibitors that bind to the aspartate protease enzyme of hiv, which is required for the virus to produce functional proteins for further hiv infection. which of the following statements are true about saquinavir and indinavir?

choose one or more:
a. very high local concentrations of proteins with phe-pro or tyr-pro peptide bonds would reduce the effectiveness of saquinavir and indinavir in limiting hiv's infectivity of new cells
b. the removal of the phenyi ring (six-membered carbon ring containing three double bonds and no attached (functional groups) on indinavir and saquinavir would likely affect their inhibitory activity
c. increasing concentrations of indinavir or saquinavir would result in a change in the a of the aspartate protease enzyme reaction
d. saquinavir and indinavir indinavir both have a component that mimics the natural phe-pro dipeptide substrate of aspartate protease

Mantle convection  is the slow  creepingmotion of earth's solid silicate  mantle  caused by  convection  currents carrying  heat from the interior  to the planet's surface.[1][2]  the earth's surface  lithosphere, which rides atop the  asthenosphere  (the two components of the  upper mantle), is divided into a number of  plates  that are continuously being created and consumed at their opposite  plate boundaries. accretion occurs as mantle is added to the growing edges of a plate, associated with  seafloor spreading. this hot added material cools down by  conduction  and  convection  of heat. at the consumption edges of the plate, the material has thermally contracted to become dense, and it sinks under its own weight in the process of  subduction  usually at an  ocean trench.[3]this subducted material sinks through the earth's interior. some subducted material appears to reach the lower mantle,[4]  while in other regions, this material is impeded from sinking further, possibly due to a phase transition from  spinel  to  silicate perovskiteand  magnesiowustite, an  endothermic reaction.[5]the subducted oceanic crust triggers  volcanism, although the basic mechanisms are varied. volcanism may occur due to processes that add buoyancy to partially melted mantle causing an upward flow due to a decrease in density of the partial melt.secondary forms of convection that may result in surface volcanism are postulated to occur as a consequence of intraplate extension[6]  and  mantle plumes.[7]it is because the mantle can convect that the  tectonic plates  are able to move around the earth's surface.[8]mantle convection seems to have been much more active during the  hadean  period, resulting in gravitational sorting of heavier molten  iron, and  nickel  elements and  sulphides  in the core, and lighter  silicate minerals  in the  mantle.

Ibelieve its b but u might have to