Aresearcher calls you stating that he plans to submit a proposal to the nih for a human subjects research study. he wants to know at what point he and his study team must submit coi disclosures to comply with the phs regulation.

Before the NIH proposal is submitted, the investigator must submit conflict of interest (COI) disclosures for all investigators that involved in the research, to the institution which review the proposal.
The submission of COI must be updated within 30 days of change that happen to the previous disclosure