Which of the following describes the MOST significant impact of Hernando de Soto’s exploration on Native Americans living in the Southeast? A. converted the American Indians to catholicism
B. built alliances with the major native tribes
C. Caused the death of hundreds of American Indians
D introduced a variety of new foods to the American Indians

C. Caused the death of hundreds of American Indians

Explanation:

His soilders killed Native Americans left and right as they invaded their land and demanded for gold and food. Many Native people also died due to the new diseases the Spanish carried.

"choosing is refusing" means individuals face an opportunity cost with each decision they make. economists state that every decision involves trade-offs. opportunity cost is the least desirable alternative given up as a result of a decision.