A similarity between English colonies and the Spanish missions in North America during the 1500s and 1600s was the creation of new industries.
the bringing of unfamiliar diseases to American Indians.
the enslavement of American Indians.
the creation of permanent European settlements.

The creation of new industries. The bringing of unfamiliar diseases to American Indians.

Explanation:

A similarity between English colonies and the Spanish missions in North America during the 1500s and 1600s was.  the creation of new industries. the bringing of unfamiliar diseases to American Indians.

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