A 4-year-old boy with Down syndrome is brought by his mother to the office for increasing fatigue, intermittent fever, and decreasing appetite for three weeks. He is previously healthy. Physical examination reveals pallor and hepatosplenomegaly. What is the best next step in the management of this child?

Send CBC and peripheral smear

Explanation:

The symptoms shows that the boy is suffering from leukemia, of which the type known as Acute Lymphocytic Leukemia is more associated with Down Syndrome.

Therefore, it will be best to send CBC and peripheral Smear.

CBC which means Complete Blood Count, evaluate the level or degree of leukemia, anemia, and White Blood Cell (WBC) count.

Also, With the help of Smear to diagnose if the child is suffering from leukemia.

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