With the coming of the personnel of organized vice took the lead in the systematic organizeation of this new and profitable field of exploitation.

With the coming of Prohibition, the personnel of organized crime took the lead in the systematic organization of this new and profitable field of exploitation.  

Explanation:  

During The Prohibition Era, alcohol was the product of severe restrictions by the Prohibitionists, "alcohol was evil and turned men into shadows of their former selves", the goal was to ban it outright.  

In 1791 in the relatively new United States the Revolutionary War had left a noticeable dent in the nation's financials to ease the strain, the idea to tax alcohol was brought up because it was considered luxury to an extent.  

In the Southern United States organized crime groups smuggled alcohol from Mexico, smuggling lords made millions off untaxed alcohol and they took advantage of this new and profitable field of exploitation.

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