According to a tv ad, "because depression is a chemical imbalance, new venlafaxine's extended release can with mood, sleep, arousal, and alertness by working on the two key neurotransmitters involved in depression." the two neurotransmitters are serotonin and:

norepinephrine

Neurotransmitters are chemical messengers in the brain that are the means by which brain cells communicate with each other. New drugs like venlafaxine are called serotonin-norepinephrine reuptake inhibitors, and their function is to target two main neurotransmitters: serotonin and norepinephrine, which are the main neurotransmitters associated with depression.

the best and most correct answer among the choices provided by the question is the second choice "less supportive to the war of 1812"

the war of 1812 was a military conflict that lasted from june 1812 to february 1815, fought between the united states of america and the united kingdom, its north american colonies, and its native american allies.

i hope my answer has come to your . god bless and have a nice day ahead!