What is the internal energy of a substance?

Internal energy is the microscopic energy contained in a substance, given by the random, disordered kinetic energy of the molecules. In addition it includes the potential energy between these molecules, and the nuclear energy contained in the atoms of these molecules

Internal energy, in thermodynamics, the property or state function that defines the energy of a substance in the absence of effects due to capillarity and external electric, magnetic, and other fields.

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