Diffusion of uric acid in protein solution and binding. uric acid (a) at 37°c is diffusing in an aqueous solution of proteins (p) containing 8.2 g protein/100 ml solution. uric acid binds to the proteins, and over the range of concentrations present, 10 g mol of acid binds to the proteins for every 3.0 g mol of total acid present part transport processes: momentum, heat, and mass in the solution. the diffusivity [tex]d_{ab}[/tex] of uric acid in water is 1.21 x 10 cms and [tex]d_p[/tex] = 0.091 x 10 cm/s (a) assuming no binding, predict the ratio [tex]d_{ap}/d_{ab}[/tex] due only to blockage effects. (b) assuming blockage plus binding effects, predict the ratio [tex]d_{ap}/d_{ab}[/tex]. com- pare this with the experimental value for [tex]d_{ap}/d_{ab}[/tex] of 0.616 (c8). (c) predict the flux in g uric acid/s. cm² for a concentration of acid of 0.05 g/l at point (1) and 0 g/l at point (2) a distance 1.5 μm away.

Physics, 29.10.2019 21:31 blueval3tine

Diffusion of uric acid in protein solution and binding. uric acid (a) at 37°c is diffusing in an aqueous solution of proteins (p) containing 8.2 g protein/100 ml solution. uric acid binds to the proteins, and over the range of concentrations present, 10 g mol of acid binds to the proteins for every 3.0 g mol of total acid present part transport processes: momentum, heat, and mass in the solution. the diffusivity $d_{ab}$ of uric acid in water is 1.21 x 10 cms and $d_p$ = 0.091 x 10 cm/s
(a) assuming no binding, predict the ratio $d_{ap}/d_{ab}$ due only to blockage effects.
(b) assuming blockage plus binding effects, predict the ratio $d_{ap}/d_{ab}$ . com- pare this with the experimental value for $d_{ap}/d_{ab}$ of 0.616 (c8).
(c) predict the flux in g uric acid/s. cm² for a concentration of acid of 0.05 g/l at point (1) and 0 g/l at point (2) a distance 1.5 μm away.

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