The effect of the drug fluoxetine (Prozac) on isolated rat brain mitochondria was examined by measuring the rate of electron transport (units not given) in the presence of various combinations of substrates and inhibitors .
(a) How do pyruvate and malate serve as substrates for electron transport?
(b) What is the effect of fluoxetine on electron transport? Explain.
(c) Fluoxetine can also inhibit ATP synthase. Why might long-term use of fluoxetine be a concern?
Rate of Electron Transport
[Fluoxetine], (mM) pyruvate + malate succinate + rotenone ascorbate + TMPD
0 163 Β± 15.1 145 Β± 14.2 184 Β± 22.2
0.15 77 Β± 7.3 131 Β± 13.5 116 Β± 13.9
Answers: 2
Another question on Medicine
Medicine, 09.07.2019 19:10
Mr rogers is 2 days postoperative of a thoracotomy of removal of a malignant mass in his left chest. his pain is being managed via epidural catheter with morphine. as the nurse assumes care of mr rogers, he is alert and fully oriented and states that his current pain is 2 on a 1 -to-10 scale. his vital signs are 37.8-92-12, 138/82. what are benefits of epidural versus systemic administration of opioids? the nurse monitors mr rogerβs respiratory status and vital signs every 2 hours. what is the rationale for this frequent assessments? the nurse monitors mr rogers for what other complications of epidural anelgesis?
Answers: 1
Medicine, 09.07.2019 19:10
You are caring for a patient with an anxiety disorder on the psychiatric unit. the family is present with the patient. your instructor talked in the mental health course about cognitive, affective, and behavioral psychiatric nursing interventions. a. what are cognitive, affective, and behavioral psychiatric nursing interventions? b. give some examples of cognitive, affective, and behavioral psychiatric nursing interventions you could apply to the care of this family.
Answers: 1
Medicine, 09.07.2019 20:20
Which of the following is the most common source of thermal injury to a patient during surgery? a. harmonic scalpel b. ligasure c. lasers d. electrosurgical unit
Answers: 2
Medicine, 09.07.2019 20:20
The concave notch in the kidney is referred to as the: a. hilum b. medulla c. calyx d. cortex
Answers: 2
You know the right answer?
The effect of the drug fluoxetine (Prozac) on isolated rat brain mitochondria was examined by measur...
Questions
Arts, 02.03.2021 19:50
Mathematics, 02.03.2021 19:50
Mathematics, 02.03.2021 19:50
Social Studies, 02.03.2021 19:50
Mathematics, 02.03.2021 19:50
Social Studies, 02.03.2021 19:50
History, 02.03.2021 19:50
Physics, 02.03.2021 19:50
