Pain in throat and loss of voice are generally a sign of

"Laryngitis is contagious if it is caused by an infection. The most common signs and symptoms of laryngitis are hoarseness, loss of voice, and throat pain. Additional signs and symptoms of laryngitis in adults may include dry, sore throat, pain with swallowing, and a feeling of fullness in the throat or neck."

activation of phospholipase c (plc) indirectly increases intracellular ions through inositol triphosphate (ip3).