A 68-year-old woman has had her mobility and quality of life severely affected by rheumatoid arthritis (RA). Place the following pathophysiological events involved in herhealth problem in the correct order that they most likely occurred. Use all the options. A) Inflammatory responseB) Interaction between rheumatoid factor (RF) and IgGC) T-cell–mediated immune responseD) Pannus invasionE) Destruction of articular cartilage

C, B, A, D, E

Explanation:

RA is thought to begin with a T-cell–mediated immune response that precipitates interaction between IgG and RF that constitutes an immune response. Pannus invasion is one consequence of this interaction, the ultimate result of which is destruction of cartilage.

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