Previous studies suggest that use of nicotine-replacement therapies and antidepressants can help people stop smoking. The New England Journal of Medicine published the results of a double-blind, placebo-controlled experiment to study the effect of nicotine patches and the antidepressant bupropion on quitting smoking. The target for quitting smoking was the 8th day of the experiment. In this experiment researchers randomly assigned smokers to treatments. Of the 162 smokers taking a placebo, 28 stopped smoking by the 8th day. Of the 272 smokers taking only the antidepressant buproprion, 82 stopped smoking by the 8th day.
Calculate the 99% confidence interval to estimate the treatment effect of buproprion (placebo-treatment). (The standard error is about 0.0407. Use critical value z = 2.576.)
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Round your answer to three decimal places. Put lower bound in the first box and upper bound in the second box.