How do you use the order of operations to simplify expression with exponent

So the trick I was taught to use was PEMDAS which stands for Parenthesis, Exponents, Multiplication, Division, Addition, and Subtraction. You solve the parenthesis first, followed by exponents if there are any. Multiplication and division are equal. So if there's multiplication and division in the problem, you solve the one closest to the left or start of the equation first. The same rules apply for addition and subtraction. They are both equal so you solve the first one first, even if the subtraction is before the addition.

Sis less than or equal to 75 (bottom left)