Which is an example of a substitution mutation? Which best summarizes the effects of mutations on organisms?

Mutations are sometimes helpful, sometimes harmful, and sometimes neutral.
Mutations are usually harmful, sometimes neutral, and never helpful.
Mutations are sometimes neutral, sometimes helpful, and never harmful.
Mutations are always harmful, never helpful, and never neutral.

1. Such a substitution could: change a codon to one that encodes a different amino acid and cause a small change in the protein produced. For example, sickle cell anemia is caused by a substitution in the beta-hemoglobin gene, which alters a single amino acid in the protein produced.

2. A - Mutations are sometimes helpful, sometimes harmful, and sometimes neutral

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if you explain the the question more correctly i might be able to answer this better

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