1. It is hypothesized that there are fluctuations in norepinephrine (NE) levels which accompany fluctuations in affect with bipolar affective disorder (manic-depressive illness). Thus, during depressive states, NE levels drop; during manic states, NE levels increase. To test this relationship, researchers measured the level of NE by measuring the metabolite 3-methoxy-4-hydroxyphenylglycol (MHPG in micro gram per 24 hour) in the patient's urine experiencing varying levels of mania/depression. Increased levels of MHPG are correlated with increased metabolism (thus higher levels) of central nervous system NE. Levels of mania/depression were also recorded on a scale with a low score indicating increased mania and a high score increased depression. The data is provided below. MHPG Affect
980 22
1209 26
1403 8
1950 10
1814 5
1280 19
1073 26
1066 12
880 23
776 28