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The Inca Empire (Quechua: Tawantinsuyu, lit. "The Four Regions"[2]), also known as the Incan Empire and the Inka Empire, was the largest empire in pre Columbian America,[3] and possibly the largest empire in the world in the early 16th century.[4] Its political and administrative structure "was the most sophisticated found among native peoples" in the Americas.[5] The administrative, political and military center of the empire was located in Cusco in modern-day Peru. The Inca civilization arose from the highlands of Peru sometime in the early 13th century. Its last stronghold was conquered by the Spanish in 1572.