On what document did southerners base the claim of nullification?

the mayflower compact
the fundamental orders of connecticut
the declaration of independence
the constitution

I believe this is from the constitution 

C, because he has a direct link and profit from the trade. the fastest way by boat to transport those goods is via the panama canal.

Cherokee  removal, part of the trail of tears, refers to the  forced  relocation between 1836 and 1839 of thecherokee  nation from  their lands ingeorgia, south carolina, north carolina, tennessee, texas, and alabama to the indian territory (present day oklahoma)  in  the thenwestern united states, and the resultant deaths