In addition to mecca, what were four other major muslim sites in 1500?

The answer is: Four other major Muslim sites in 1500 were Malacca, Herat, Samarq and Cairo.

Explanation:

Muslim got scattered in a trade route between Asia and the Far East, then it consolidated because of the growth of the territory of converted rulers and their clanship. Some of the Muslim sites that took more strength were the ones mentioned before, because of several factors like social position, and strategic location.

during world war ii                                                      

the western roman empire flourished, but the eastern portion of the empire struggled.