The U. S. invasion of Afghanistan in 2001 led to: A. The total defeat of Al-Qaeda
B. Many terrorists groups relocating to Pakistan
C. Major terrorist attacks in the United States
D. The Taliban taking control of the country

the U.S. invasion of Afghanistan in 2001 led to B, Many terrorist groups relocating to Pakistan

Explanation:

Dubbed “Operation Enduring Freedom” in U.S. military parlance, the invasion of Afghanistan was intended to target terrorist mastermind Osama bin Laden's al-Qaida organization, which was based in the country, as well as the extreme fundamentalist Taliban government that had ruled most of the country since 1996

It held control of most of the country until being overthrown after the American-led invasion of Afghanistan in December 2001 following the September 11 attacks.

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Taliban.

Taliban طالبان (Pashto)

HeadquartersKandahar, Afghanistan (1996–2001)

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representative government