What started sectionalism in the United States in 1816?

Sectionalism, or regional conflict between the Northern and Southern United States in the early to mid-19th century, was caused by many factors, with slavery, the "Slave Power Conspiracy," economic and cultural differences between the two sections being the primary four factors.

Explanation:

necessary and proper clause. the congress shall have power to all laws which shall be necessary and proper for carrying into execution the foregoing powers, and all other powers vested by this constitution in the government of the united states, or in any department or officer thereof.