What was a major cause of regional conflicts in the United States when Kansas and Nebraska were added as new territories ?

What was the primary concern for the missouri statehood question

The idea of liberalism in eighteenth-century british politics: a. had mainly a civic and social quality. b. prompted two eighteenth-century leaders, joseph mccarthy and hugh mccarran, to demand independence for ireland. c. brought great wealth and power to its main voice, john locke. d. was compatible with inequalities in wealth and well-being. e. had the same meaning as liberalism in twenty-first-century american politics.

Mississippi, florida, alabama, georgia, louisiana, and texas all seceded from the union. true or false ?