The Virginia Company chose the inland site for Jamestown because it was not controlled by the Powhatan American Indians.
easy to defend from the Spanish.
easy to defend from American Indians.
on a river that did not have swamps.

Easy to defend from the Spanish

Explanation:

The land was surrounded by water on three sides and a swamp on the fourth. The fort was also located at a river bend which made it easy to see any oncoming attackers.

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um is there supposed to be choices?