PLEASE HELP What seems to be the main grievance for the native Americans in their fights with the settlers

Me! these questions are based on american people in the south essential questions: question 1: for what reasons will one group of people exploit another? focus questions: question 1: what influenced the development of the south more: geography, economy, or slavery? question 2: what were the economic, political and social arguments for and againsts slavery in the first half of the 19th century.