Why did westward expansion lead to conflicts between the Plains Indians, white settlers, and the U. S. government?

Explanation: There was a clash of cultures between the Native Americans and the White Settlers. As a result, the Native Americans felt that the white settlers were ruining the earth and the settlers distrusted and feared the Natives. 2) Manifest Destiny resulted in the white settlers taking over the land. Buffalo was the main food source for Plains Indians. ... Westward expansion impacted the culture of the Plains Indians. The Plains Indians viewed the Great Plains and its roaming buffalo as sacred and a resource for survival. By contrast, many white people viewed the land and buffalo as a resource to produce wealth.

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