Do you think that the relationship between the settlers and the American Indians effected the success or failure of the settlements?

yes, i do.

Explanation:

the relationship between the settlers and american indians was far from perfect. early settlers arrived with diseases that many american indians died from, and let's not forget the trail of tears when american indians were forced to relocate. there were even times when american indians fought back and attacked settler at their settlements.

if the settlers had been fair and honest with the american indians from the start, the settlements could've been much more successful, attacked less, and the relationship between them and settlers could've been much better.