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in what way would a secessionist defend the actions of south carolina as the state
left the union?

since a republican was elected president, south carolina had no choice but to
secede to protect its way of life.

as a part of the compromise of 1850, the constitution was amended to allow
the states to secede from the union.

o new england states had seriously considered secession during the war of 1812,

so it was a valid action.
the political theory of popular sovereignty claimed that the people of a state
had a right to vote for secession.

Since the Republicans had been elected as president, South Carolina had no preference but to secede to safeguard its way of life.

Explanation:

Around December 20, 1860, South Carolina separated from the US. That's because Abraham Lincoln, the Democrat, was named chairman. The Republicans were a new political party and Lincoln became the first President to be elected. They tried to stop the spread of oppression to the west.

Southern states felt they used to have a constitutional right, even slaves, to acquire property everywhere.

Since secession, South Carolina faced many problems. The most serious issue was the issue of federal government owned property. Many forts all across Charleston Harbour were located in the United States. Fort Moultrie's men were less than 70. Only one was in Castle Pinckney. Yet Fort Sumter–still under construction–had none.  

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thus is very possible the existence of both scenarios, where populations of isolated individuals have different genetic traits, and share traits related to genetic mutation, due rats can easily travel overseas using human transport channels. so scientists could get a vast number of data, including human interaction, evolution of rodents, health development, spread of infections, development of new organisms, how genomes evolve in different environments and so on.