Which was not a reason for the growth of american cities qlong rivers in the mid-1800s

Lo cual no fue una razón para el crecimiento de las ciudades estadounidenses en los ríos qlong a mediados del siglo XIX.

the answer in english is, Rivers served as a defensive barrier against disease.

Explanation:

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disease was the number one killer of native peoples. they had had little exposure to the diseases of europe. this led to some villages being almost completely wiped out and some tribes destroyed.