If the rate of elimination of a drug is 0.3/hour, find the half-life of elimination

achieve a therapeutic objective (cure disease, mitigate symptoms etc.)

minimize toxicity

minimize difficulty of administration

identify dosing regimensList the goals of drug therapytherapeutic window/rangethe plasma concentration range that is effective and safe in treating specific diseasestrue(T,F): The therapeutic response is dependent on drug achieving an adequate plasma concentrationmultiple doses are given to stay in the therapeutic windowvolume of distribution (V)an important indicator of the extent of drug distribution into body fluids and tissues

relates the amount of drug in the body to the measured concentration in the plasma

it is the volume required to account for all of the drug in the body if the concentration in all tissues is the same as the plasma tissue.clearancethe process of removing a drug from plasma (expressed as volume of plasma per a given unit of time)true(T,F): Clearance indicates the volume of plasma (or blood) from which the drug is completely removed, or cleared, in a given time period.half-lifevolume of distribution and clearance influences the of a drug. 

Dosing regimen: How often?oral bioavailabilityclearance and absorption influences the of a drug

Dosing regimen: How much?steady statethe amount of drug administered is equal to the amount of drug eliminated within one dosing interval resulting in a plateau or constant serum drug levelshortDrugs with a half-life reach steady state rapidlylongDrugs with a half-life take days to weeks to reach steady statetherapeutic windowA steady state is desired within the half-lifethe time necessary for the concentration of drug in the plasma to decrease by one-half (50%)about 5How many half-lives are required to reach steady state?loading dosesoften administered at the initiation of an infusion to achieve an immediate therapeutic plasma concentration of the drug (allows rapid achievement of therapeutic serum)true(T,F): The same loading dose is used regardless of metabolism/elimination dysfunction

Only ten amendments were ratified by the states.