Which of these is a significant risk with prolonged use of OTC medications?

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Explanation:

Research shows that the risks involved with using OTC drugs include addiction issues because of prolonged use, adverse drug interactions and reactions, improper self-diagnosis, and inappropriate dosing.

digital rectal exam (dre) a digital rectal exam (dre) is a test for both men and women. it allows a doctor to check the lower rectum, pelvis, and lower belly for cancer and other health problems, including: prostate cancer in men.

i-i-i-i-i-i don't k-k-k-k-know.