During the last few years, 75-year-old mrs. esterhouse has gradually become so mentally disoriented that she can't find her way around her own house and often fails to recognize her husband. it is most likely that mrs. esterhouse is suffering the effects of:

Hey there!

Mrs. Esterhouse is likely suffering from Alzheimer's disease. Alzheimer's involves a decline in thinking and memory ability and sufferers often become much more disoriented and unable to recognize familiar surroundings than before. It's a progressive and degenerative disease without a known cause that's one of the causes of dementia. 

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Its simple its a because they are more fat

Smoking damages the respiratory system by inhalation of a foreign substance, that is absorbed and residue is left behind on our lungs sponge like substance. the gas that is inhaled also increase your blood pressure and dilates your blood vessels. also the process of inhaling and exhaling the smoke it causes irritation to the throat and mouth. smoking can cause lung cancer and other respiratory and circulatory diseases.