Enzo sits with a small group of friends at lunch. Lately, he has been very quiet and stays home a lot even though his friends invite him to go places. He likes to play video games in his free time and is slightly overweight. Which behavior is a sign that Enzo may need professional mental health treatment?

Adouble-blinded trial for a new indication is conducted under an ind comparing two (2) marketed drugs, at twice the approved prescribed doses. on day 2, subject 603 had difficulty breathing. although it was life-threatening initially, subject 603 was treated and discharged directly from the emergency department after complete recovery. on day 5, subject 20 had a headache, which led to hospitalization and required blood pressure lowering medications. these episodes cannot be explained on the basis of the pharmacological property of either drug or the subjects' medical histories. the investigator would submit an sae report for