According to the CDC smoking can lead to buergers
disease which affects blood vessels in the arms and legs blood vessel swell which can prevent blood flow causing clots to form this can lead to pain in tissue damage extreme cases can induce gangrene which can require amputation

According to the CDC, smoking can lead to Buerger's  disease which affects blood vessels in the arms and legs blood vessel swell which can prevent blood flow causing clots to form this can lead to pain in tissue damage extreme cases can induce gangrene which can require amputation is a true statement. Extreme conditions may require amputation and needs more care.

Explanation:

Buerger’s disease can affect anyone using tobacco in any form like smoking cigarettes or cigars, chewing tobacco, etc.  

The tobacco irritates the blood vessel lining which leads to swelling of blood vessels, prevents the blood flow, and causes blood clots. Due to this constriction of blood flow, the tissues in various parts of the body get affected with poor blood supply causing tissue damage and necrosis which may result in gangrene.  

As per the CDC report, the gangrenes due to Beurger’s disease can become very severe or extreme that may require amputation of the part affected like even removal of a limb. These extreme cases require a lot of care involving involuntary care to treat.  

Hence the CDC advises to refrain from tobacco in any form to prevent this disease.