Manuel has lung cancer, Nadine has cirrhosis of the liver, Olive has celiac disease, and Pierre has sleep apnea. Which one of these four individuals is most likely experiencing the negative health effects of being overweight or obese?

The individual with the most likely negative effect of overweight and obesity is Pierre who has sleep apnea.

Explanation:

Sleep apnea is a condition in which the airways are temporarily obstructed during sleep, making inhalation and exhalation difficult.

This condition results in reduced oxygen supply to the blood cells and accumulation of carbondioxide in the blood, and this hypoventilation can result in intermittent waking up of the patient throughout the period of sleep.

In adults, this condition is most commonly cause by obesity and overweight which leads to an excess deposition of fatty tissues in the soft tissues of the mouth and throat, and during sleep, when the muscles of the mouth and throat relax, these excess fatty tissues collapse, closing briefly the airways, resulting in difficulty in breathing.

other factors that can contribute to the development of sleep apnea are;

excessively thick neck, enlarged tonsils and adenoids, Down's syndrome, Pierre-Robinson syndrome, smoking and excessive alcohol use.

The other conditions mentioned in the questions are not directly related to obesity and overweight.