A14-year-old girl presents with right thigh pain that has been going on for the last month. she recalls being kicked in the leg during soccer practice before her symptoms started. she was last seen in the ed two weeks ago and was diagnosed with a muscle contusion. on exam there is a mass palpable over the anterior distal thigh. x-ray of the femur shows a distal femoral diaphyseal lesion with cortical destruction and periosteal reaction with high suspicion for osteosarcoma. which of the following is true regarding this disease

Taking into account that the alternatives to this case are:

a.Blunt trauma is associated with the pathogenesis of osteosarcoma.

b.Ionizing radiation for childhood cancer is  a risk factor for osteosarcoma.

c.Osteosarcoma most often involves the axial squeleton followed by the long bones.

d.Pathologic fracture is a common presenting sign

The right answer is the option B

Explanation:

In previous medical analysis and research of the disease, sarcomas were one of the first solid cancers to be found connected with ionizing radiation exposure.  The risk of both bone and soft tissue sarcomes are very high after high-dose fractionated radiation (10+Gy) in  childhood.