You have altered the menu of food items served to your patients. however, the change
has greatly expanded the number of refrigerated items needed on hand. you need to buy a
new refrigerator, but the electric circuit in the kitchen cannot handle the extra load and
needs to be upgraded at significant expense. this set of unintended consequences down
the line nroduced by an initial change, is called:

Adouble-blinded trial for a new indication is conducted under an ind comparing two (2) marketed drugs, at twice the approved prescribed doses. on day 2, subject 603 had difficulty breathing. although it was life-threatening initially, subject 603 was treated and discharged directly from the emergency department after complete recovery. on day 5, subject 20 had a headache, which led to hospitalization and required blood pressure lowering medications. these episodes cannot be explained on the basis of the pharmacological property of either drug or the subjects' medical histories. the investigator would submit an sae report for