Blood sugar is regulated by two pancreatic hormones—insulin and glucagon. when blood sugar rises, insulin is released; it binds to receptors and, through signal transduction, results in an increase in glucose uptake by cells, which effectively lowers blood glucose levels. when blood sugar decreases, glucagon is released, binds to cell receptors, and causes glucose to be released into circulation, thereby increasing blood glucose levels. diabetes mellitus is a disorder that results from excessively high levels of blood glucose. type ii diabetics have normal to elevated levels of insulin. what, then, might be causing their elevated blood glucose levels?